Switch Contrast

Poepsel Lab

New Article on AIFM1: Collaboration with the Riemer Lab

07/02/2025

Our work on the human mitochondrial redox-factor AIFM1 has just been published in Molecular Cell. Wonderful collaboration with the group of Jan Riemer at the Institute of Biochemistry

Figure AIFM1
Figure AIFM1
Figure AIFM1

AIFM1 has been proposed to play pro-apoptotic roles, but is now increasingly recognized for its function controlling energy metabolism in the mitchondrial intermembrane space. In a with the group of Jan Riemer we have defined the interactions of AIFM1 with its partners MIA40 and AK2 by solving high-resolution structures using single-particle cryo-electron microscopy. Amazing work in particular by the first authors, Alex (Riemer Lab) and Egor (Poepsel Lab) - you've done fantastic work!! Also a big thank you to Elmar Behrmann and Monika Gunkel for their support at the StruBiTEM cryo-EM facility here in Cologne. Some of the data was also collected with the help of Christos Gatsiogiannis at the Center for Soft Nanoscience in Münster. 

Back